* item room, treasure room, item room pool, dice pip, starting, pyramid, green, triange. Synergizes well with a lot of tear effects - e.g. Can be negated with Black Candle, Bad Gas - Isaac farts, poisoning enemies around him, Bombs are key - Switches number of bombs and keys, Explosive Diarrhea - Spawns five live troll bombs behind Isaac, one per second, Full Health - Restores all your empty red heart containers, Health Down -1 HP. * item room, treasure room, item room pool, round, circle, white, * item room, treasure room, item room pool, grey, gray, bent. Unlocked from the 'U broke it!' A familiar which follows Isaac and shoots two normal tears at once in a V-shaped pattern.
* item room, treasure room, item room pool, jar, bottle, purple, label. If your speed stat is already higher then that value is still used. Getting all these items in a single run usually requires the use of a strategy to create infinite items and exhaust the item pool, like, Substituting Clicker with items that revive you as another character upon death will allow you to get the extra completion marks for. Gives Isaac an eye companion that floats around the room and deals 8 damage per tick on contact with enemies. The chance to poison enemies is affected by your luck stat and at +18 Luck it will activate every time. After taking damage, if you have half a red heart or less, The Polaroid will give you an invincibility shield for 5 seconds. (Does not change your trinkets, pills or cards), 2 Dot - Rerolls all pickups in the room. *, the lost item pool, brown, pink, lump, ball, spot. UNLOCK: Unlock this item by beating Boss Rush with The Lost. Reveals adjacent room types, this includes revealing if you're next to a Secret Room or Super Secret Rooms. Each of Harlequin Baby's tears deal 4 damage. * dungeon room, blood challenge room, arena pool, item room, treasure room, item room pool, Has a partial Magneto effect and will attract coins, pulling them into Isaac from a distance.
Finding all the puzzle pieces will help you to reveal the final secret, unlocking the hidden character 'The Lost'. The highest damage orbital in the game, dealing 225 damage per second.
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